Medicinal Cannabinoid for Sleep Disorders
Human experimental data suggests cannabis and THC have a dose-dependent effect on sleep. Low doses appear to decrease sleep onset latency and increase slow-wave sleep and total sleep time, while high doses appear to cause sleep disturbances .
Limited evidence from clinical studies also suggests that certain cannabinoids (cannabis, nabilone, dronabinol, nabiximols) may improve sleep in patients with disturbances in sleep associated with certain chronic disease states.
A number of clinical studies point to a potential beneficial role for smoked cannabis or prescription cannabinoids (dronabinol, nabilone, nabiximols) in the treatment of sleep difficulties or disturbances associated with chronic pain (cancer pain, chronic non-cancer pain, diabetic peripheral neuropathy), HIV-associated anorexia-cachexia, MS, ALS, SCI, RA, fibromyalgia, inflammatory bowel disease (IBD), MS-associated bladder dysfunction, PTSD, chemosensory alterations and anorexia-cachexia associated with advanced cancer  -  - .
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